Chemical Structure and Physical Properties of Matrixyl 3000

 Matrixyl 3000 is a trademarked peptide complex widely used in anti-aging skincare. It isn’t a single pure chemical compound, but a blend of two synthetic peptides designed to signal skin cells and promote collagen and extracellular matrix production.

Component Peptides

Matrixyl 3000 is composed of two palmitoylated peptides:

1. Palmitoyl Tripeptide-1

• A peptide with three amino acids (often derived from a sequence including glycine–histidine–lysine, Pal-GHK) linked to palmitic acid (a C16 fatty acid).

• Palmitoylation increases lipid solubility and helps the peptide penetrate the skin.

2. Palmitoyl Tetrapeptide-7

• A four–amino-acid peptide (Pal-GQPR) also linked to palmitic acid.

• Works synergistically with the tri-peptide to reduce inflammatory signaling and support skin repair.

These two peptides together form the Matrixyl 3000 complex.

Chemical Structure of Matrixyl 3000

Matrixyl 3000 doesn’t have a single molecular formula because it’s a mixture of two distinct peptides:

1. Palmitoyl Tripeptide-1:

• A peptide chain of three amino acids covalently bonded to palmitic acid

• Example generalized formula (for one component): CnHmNoOp depending on exact sequence and peptide length

• Reported CAS for palmitoyl-Gly-His-Lys type peptides: 147732-56-7 for palmitoyl tripeptide-1.

2. Palmitoyl Tetrapeptide-7:

• Four amino acids linked to palmitic acid

• Reported CAS for palmitoyl tetrapeptide-7: 221227-05-0.

In commercial raw powder form, some sources list a separate CAS for combined peptide complexes like Matrixyl; e.g., 77727-17-4 has been referenced in synthetic peptide supply listings (though individual component CAS are the true identifiers).

Structure summary:

• N-terminal palmitoyl (C16 fatty acid) tail → peptide sequence → C-terminal free amino group (or amide depending on synthesis).

• The palmitoyl chain improves skin penetration and lipophilicity relative to unmodified peptides.

Physical Properties of Matrixyl 3000

Matrixyl 3000 in raw peptide form (powder) has these general characteristics:

Property	Typical Value / Description
Appearance (raw)	White to off-white fine powder (lyophilized)
Solubility	Soluble in water (for formulation into serums/aqueous solutions)
Stability	Stable as lyophilized powder; peptides can degrade with heat or extreme pH
Melting Point (reported)	~224–227 °C (for powder complex preparation)
Physical Form in Cosmetic Formulations	Clear/pale liquid or gel when delivered in glycerin/water blends
pH Range in Formulations	Compatible typically around pH 4–7

In finished skincare products, Matrixyl 3000 is typically supplied as a liquid or gel suspension in water, glycerin, and humectants rather than as a standalone solid.

Functional Notes

• Palmitoylation: The fatty acid (palmitic acid) attached to each peptide increases their lipophilicity, helping them penetrate the stratum corneum more effectively than unmodified peptides.

• Mechanism: The peptides mimic matrikines (matrix fragments) that signal skin cells to produce collagen and other extracellular matrix components.

Summary

• Matrixyl 3000 = blended peptide complex (palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7).

• Chemical nature: synthetic short peptides with palmitic acid modifications to bolster skin delivery.

• Physical form: white to off-white powder (raw), water-soluble for cosmetic use.

If you’d like, I can also provide structural diagrams or amino-acid sequences for the peptide components!

From cellsbio health technology co.,ltd