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Basic Information of Tranexamic Acid

 Tranexamic acid (TXA) is a synthetic antifibrinolytic agent used to prevent or reduce excessive bleeding by inhibiting plasminogen activation, thereby stabilizing blood clots.

General Information of Tranexamic Acid

  • Name: Tranexamic Acid
  • Chemical Formula: C₈H₁₅NO₂
  • Molecular Weight: 157.21 g/mol
  • Drug Class: Antifibrinolytic agent

Mechanism of Action

Tranexamic acid works by inhibiting plasminogen activation, preventing the breakdown of fibrin clots. This helps reduce excessive bleeding.

Basic Information of Tranexamic Acid

Uses of Tranexamic Acid

  • Treatment of heavy menstrual bleeding (menorrhagia)
  • Prevention and treatment of bleeding in hemophilia patients
  • Postoperative bleeding prevention (e.g., after dental extraction in hemophilia patients)
  • Control of bleeding in trauma and surgery
  • Treatment of hereditary angioedema

Dosage

  • Oral: Typically 1-1.5 g, 2-3 times daily for a few days (varies by condition)
  • IV: Dose varies depending on indication (e.g., 10 mg/kg for surgical use)
  • Topical: Used in some formulations for skin discoloration treatment

Side Effects of Tranexamic Acid

  • Nausea, vomiting, and diarrhea
  • Headache and dizziness
  • Risk of blood clots in some cases
  • Allergic reactions (rare)
Basic Information of Tranexamic Acid

Contraindications

  • History of blood clots (deep vein thrombosis, pulmonary embolism)
  • Active intravascular clotting conditions
  • Severe kidney disease without dose adjustment

Precautions

  • Use cautiously in patients with a history of thromboembolic disorders
  • Adjust dosage in renal impairment
  • Not recommended for use with certain clot-promoting conditions

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